Himansha Singh

4th year student with The Department of Pharmacology

Although antibiotic resistance is a global health threat, combating it is limited because we don’t fully understand its progression. Drug efflux pumps/Multidrug-resistance-proteins (MDRPs) present in cell membrane are one of the contributory factors. They export drugs across cells rendering them resistant but their mechanism is elusive. My research describes a novel transport mechanism of drugs by one of the classes of MDRPs. The findings provide us state-of-the-art options for the development of inhibitors for these pumps. These inhibitors will help further understand resistance and aid in designing new antibiotics. Additionally, they could be used in combination therapy with existing antibiotics

Update

Himansha Singh has been profiled by the University of Cambridge as a postgraduate pioneer:

http://www.cam.ac.uk/news/postgraduate-pioneers-2017-1