Dhruv Panchal

Clinical Neurosciences

Dementia features an early and currently irreversible loss of neuronal connections essential for brain function. Hibernating animals can regenerate these connections after a bout of hypothermia during hibernation. By cooling mice modelling dementia, our group mimicked hibernation and observed dramatic improvements in outcomes. They then identified a key protein regulating this effect. In my PhD, I have discovered a neuronal cold sensor which, when targeted with a drug, induces this protein without cooling. This drug increases survival in a mouse model of dementia. This could represent a novel treatment for dementia and other diseases where cooling is used for neuroprotection.

Other 2020 award winners

David Brossault

Eleanor Brown

Jenna Rose DiRito

Francisco Huhn

Nabila Idris

Lachlan Jardine

Iek Man Lei

Theodor Lundberg

Hugo Poplimont

Tianren Yang

Previous award winners

Find out about the winners awarded in previous years: